Fig. 3
From: In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine
5fC is enriched at active enhancers in vivo. a Screenshot of a genomic region on chromosome 2 exemplifying the striking overlap of the 5fC signal with regions marked by H3K4me1 (orange boxes) and H3K27ac (purple boxes), as calculated in [27]. b Fold enrichment of 5fC peaks in hindbrain and heart from WT and Tdg null embryos over regions marked by H3K4me1, H3K4me3 and H3K27ac in the brain and heart of E14.5 embryos, respectively. Log2 fold enrichment was calculated for each replicate individually using 10,000 randomisations in a simulation procedure implemented with the GAT. Plotted is the average enrichment with standard deviation. c Comparison of 5fC peak enrichment in the hindbrain in regions marked by different histone modifications in the E14.5 mouse brain