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Table 6 DNA methylation of MR-identified CpGs was associated with gene expression of genes involved in lipid metabolism

From: Blood lipids influence DNA methylation in circulating cells

   Chr Position Mean DNAm (%) Gene Estimate (logCPM/β)a P value Chromatin state
TG cg00574958 11 68,607,623 12 CPT1A −3.3 (−4.1,−2.5) 1.5 × 10−14 Flanking active TSS
  cg17058475 11 68,607,738 14 CPT1A −1.7 (−2.3,−1.1) 1.8 × 10−8 Enhancer
  cg11024682 17 17,730,095 26 SREBF1 −2.4 (−2.8,−2.0) 5.2 × 10−33 Enhancer
LDL-C cg27168858 1 55,351,660 78 DHCR24 −4.1 (−4.9,−3.3) 2.4 × 10−25 Flanking active TSS
HDL-C cg27243685 21 43,642,367 83 ABCG1 −4.5 (−5.4,−3.6) 4.0 × 10−24 Flanking active TSS
  cg06500161 21 43,656,588 60 ABCG1 −5.1 (−5.7,−4.5) 1.2 × 10−56 Weak transcription
  1. CpGs are located in regions of active gene regulation
  2. a Estimate is the log counts per million change in gene expression per β (0–1) change in DNA methylation
  3. DNAm DNA methylation