Table 6 DNA methylation of MR-identified CpGs was associated with gene expression of genes involved in lipid metabolism
From: Blood lipids influence DNA methylation in circulating cells
|  |  | Chr | Position | Mean DNAm (%) | Gene | Estimate (logCPM/β)a | P value | Chromatin state |
|---|---|---|---|---|---|---|---|---|
TG | cg00574958 | 11 | 68,607,623 | 12 | CPT1A | −3.3 (−4.1,−2.5) | 1.5 × 10−14 | Flanking active TSS |
|  | cg17058475 | 11 | 68,607,738 | 14 | CPT1A | −1.7 (−2.3,−1.1) | 1.8 × 10−8 | Enhancer |
|  | cg11024682 | 17 | 17,730,095 | 26 | SREBF1 | −2.4 (−2.8,−2.0) | 5.2 × 10−33 | Enhancer |
LDL-C | cg27168858 | 1 | 55,351,660 | 78 | DHCR24 | −4.1 (−4.9,−3.3) | 2.4 × 10−25 | Flanking active TSS |
HDL-C | cg27243685 | 21 | 43,642,367 | 83 | ABCG1 | −4.5 (−5.4,−3.6) | 4.0 × 10−24 | Flanking active TSS |
|  | cg06500161 | 21 | 43,656,588 | 60 | ABCG1 | −5.1 (−5.7,−4.5) | 1.2 × 10−56 | Weak transcription |