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Table 4 Estimated effect of TG, LDL-C, and HDL-C levels on DNA methylation using an approach based on Egger regression to exclude pleiotropic effects, including P values for an estimate of net pleiotropic effects of the PS SNPs

From: Blood lipids influence DNA methylation in circulating cells

   Chr Position Mean DNAm (%) Estimate (%/SD)a P value Pleiotropy P value
TG cg00574958 11 68,607,623 12 −1.1 (-1.4, -0.7) 5.7 × 10−9 0.37
  cg17058475 11 68,607,738 14 −1.3 (-1.8, -0.8) 2.3 × 10−7 0.82
  cg11024682 17 17,730,095 26 0.9 (0.3, 1.5) 1.9 × 10−3 0.50
  cg27243685 21 43,642,367 83 0.7 (0.3, 1.1) 6.4 × 10−4 0.18
  cg06500161 21 43,656,588 60 1.4 (0.8, 2.0) 2.9 × 10−6 0.75
LDL-C cg27168858 1 55,351,660 78 0.7 (0.1, 1.3) 3.1 × 10−2 0.36
HDL-C cg27243685 21 43,642,367 83 0.3 (-0.9, 1.5) 0.62 0.79
  cg06500161 21 43,656,588 60 −0.1 (-1.8, 1.7) 0.93 0.15
  1. a Estimate is the percentage change in DNA methylation per standard deviation change in lipid levels
  2. DNAm DNA methylation