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Table 3 Estimated effect of TG, LDL-C, and HDL-C levels on DNA methylation using a multivariable MR analysis to exclude pleiotropic effects

From: Blood lipids influence DNA methylation in circulating cells

   Chromosome Position Mean DNAm (%) Estimate (%/SD)a P value
TG cg00574958 11 68,607,623 12 −0.7 (−1.2, −0.3) 1.5 × 10−3
  cg17058475 11 68,607,738 14 −1.0 (−1.6, −0.3) 2.5 × 10−3
  cg11024682 17 17,730,095 26 1.0 (0.3, 1.7) 5.4 × 10−3
LDL-C cg27168858 1 55,351,660 78 1.4 (0.5, 2.3) 3.1 × 10−3
HDL-C cg27243685 21 43,642,367 83 −0.7 (−1.1, −0.3) 2.2 × 10−3
  cg06500161 21 43,656,588 60 −1.1 (−1.8, −0.5) 3.5 × 10−4
  1. a Estimate is the percentage change in DNA methylation per standard deviation change in lipid levels
  2. DNAm DNA methylation