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Table 3 Estimated effect of TG, LDL-C, and HDL-C levels on DNA methylation using a multivariable MR analysis to exclude pleiotropic effects

From: Blood lipids influence DNA methylation in circulating cells

  

Chromosome

Position

Mean DNAm (%)

Estimate (%/SD)a

P value

TG

cg00574958

11

68,607,623

12

−0.7 (−1.2, −0.3)

1.5 × 10−3

 

cg17058475

11

68,607,738

14

−1.0 (−1.6, −0.3)

2.5 × 10−3

 

cg11024682

17

17,730,095

26

1.0 (0.3, 1.7)

5.4 × 10−3

LDL-C

cg27168858

1

55,351,660

78

1.4 (0.5, 2.3)

3.1 × 10−3

HDL-C

cg27243685

21

43,642,367

83

−0.7 (−1.1, −0.3)

2.2 × 10−3

 

cg06500161

21

43,656,588

60

−1.1 (−1.8, −0.5)

3.5 × 10−4

  1. a Estimate is the percentage change in DNA methylation per standard deviation change in lipid levels
  2. DNAm DNA methylation