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Table 2 Associations between log TG, LDL-C, and HDL-C levels and DNA methylation

From: Blood lipids influence DNA methylation in circulating cells

   Chromosome Position Mean DNAm (%) Estimate (%/SD)a P FDR
TG cg14476101 1 120,255,993 63 −0.8 (−1.0, −0.6) 2.6 × 10−8
  cg19693031 1 145,441,553 73 −0.6 (−0.8, −0.5) 5.2 × 10−9
  cg06690548 4 139,162,809 85 −0.6 (−0.7, −0.5) 5.7 × 10−12
  cg05575921 5 373,379 79 −0.9 (−1.3, −0.6) 4.3 × 10−3
  cg14817490 5 392,921 32 −0.5 (−0.6, −0.3) 3.3 × 10−2
  cg06560379 6 44,231,306 12 −0.2 (−0.2, −0.1) 4.0 × 10−2
  cg19589396 8 103,937,375 69 −0.4 (−0.5, −0.2) 7.6 × 10−3
  cg07504977 10 102,131,013 41 0.5 (0.3, 0.6) 2.4 × 10−4
  cg11376147 11 57,261,199 21 −0.2 (−0.3, −0.1) 7.3 × 10−3
  cg00574958 11 68,607,623 12 −0.4 (−0.5, −0.3) 2.4 × 10−23
  cg17058475 11 68,607,738 14 −0.4 (−0.5, −0.3) 7.9 × 10−7
  cg12556569 11 116,664,040 26 2.4 (1.5, 3.4) 1.4 × 10−2
  cg15863539 17 17,716,951 79 0.2 (0.1, 0.3) 1.3 × 10−3
  cg20544516 17 17,717,184 73 0.3 (0.2, 0.4) 1.1 × 10−3
  cg11024682 17 17,730,095 46 0.5 (0.3, 0.6) 3.8 × 10−11
  cg08857797 17 40,927,700 57 0.4 (0.3, 0.6) 7.3 × 10−3
  cg03636183 19 17,000,586 68 −0.6 (−0.8, −0.3) 1.3 × 10−2
  cg02711608 19 47,287,965 24 −0.3 (−0.4, −0.2) 3.9 × 10−2
  cg27243685 21 43,642,367 83 0.4 (0.4, 0.5) 8.4 × 10−20
  cg01881899 21 43,652,705 13 0.3 (0.2, 0.3) 1.7 × 10−4
  cg06500161 21 43,656,588 60 0.7 (0.6, 0.8) 1.5 × 10−29
LDL-C cg27168858 1 55,351,660 78 0.4 (0.3, 0.6) 5.3 × 10−3
  cg00908766 1 109,817,497 59 1.0 (0.6, 1.3) 2.3 × 10−2
  cg05119988 4 166,251,190 59 0.5 (0.3, 0.6) 1.4 × 10−4
HDL-C cg17901584 1 55,353,707 53 0.7 (0.5, 0.9) 1.2 × 10−4
  cg26313301 19 11,219,616 87 −0.2 (−0.3, −0.1) 3.6 × 10−2
  cg27243685 21 43,642,367 83 −0.4 (−0.5, −0.3) 1.2 × 10−9
  cg06500161 21 43,656,588 60 −0.7 (−0.8, −0.5) 1.3 × 10−13
  1. aEstimate is the percentage change in DNA methylation per standard deviation change in lipid levels
  2. DNAm DNA methylation