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Table 1 Characteristics of the six cohorts in the BIOS Consortium

From: Blood lipids influence DNA methylation in circulating cells

 

CODAM

LL

LLS

NTR

PAN

RS

Number of individuals

164

748

785

692

184

723

RNA-Seqa

159

616

650

  

619

Gender (% male)

50

42

48

32

60

42

Age (years) [SD]

65.6 [6.8]

45.6 [13.3]

58.4 [7.5]

34 [12.1]

62.4 [9.4]

67.6 [6.0]

TG (mmol/L) [SD]

1.6 [0.8]

1.2 [0.9]

1.9 [1.2]

1.3 [0.7]

1.9 [1.1]

1.5 [0.9]

LDL-C (mmol/L) [SD]

3.6 [1.0]

3.0 [0.9]

3.4 [1.0]

2.8 [0.8]

3.4 [0.9]

3.3 [0.9]

HDL-C (mmol/L) [SD]

1.3 [0.3]

1.5 [0.4]

1.4 [0.4]

1.4 [0.9]

1.4 [0.4]

1.5 [0.4]

Monocytes (%) [SD]

7.9 [1.6]

8.5 [2.2]

5.5 [1.5]

7.7 [2.0]

6.8 [1.1]

7.1 [2.1]

Lymphocytes (%) [SD]

51.2 [14.0]

34.5 [7.4]

29.2 [6.9]

35.1 [7.8]

31.8 [7.1]

36.3 [7.9]

Neutrophils (%) [SD]

40.7 [6.9]

53.3 [8.0]

59.8 [7.7]

52.6 [7.7]

55.3 [7.0]

48.3 [7.1]

  1. aThe number of individuals for which RNA-Seq data were available
  2. CODAM Cohort on Diabetes and Atherosclerosis Maastricht, LL LifeLines, LLS Leiden Longevity Study, NTR Netherlands Twin Register, PAN Prospective ALS Study Netherlands, RS Rotterdam Study, SD standard deviation