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Fig. 5 | Genome Biology

Fig. 5

From: Widespread parainflammation in human cancer

Fig. 5

Cancer parainflammation resembles macrophage infiltration. a Heatmap of the Spearman correlations between the PI score and immune functional gene sets across different cancer types. Correlations in CCLE are shown as well (Additional file 3: Tables S5 and S6). b Heatmap of the Spearman correlations between the PI score and the immune subset enrichments calculated using gene sets (Additional files 6 and 9) across different cancer types derived from both TCGA (T) and CCLE (C). Similar correlation trends are observed for a cancer type whether the data were derived from TCGA or CCLE, suggesting that the correlation is due not to association of PI with immune subset presence but to shared functionality with the gene signatures. PAAD pancreatic adenocarcinoma, BLCA bladder carcinoma, HNSC head and neck squamous cell carcinoma, LUAD lung adenocarcinoma, LUSC lung squamous cell carcinoma, COAD colon adenocarcinoma, OV ovarian serous cystadenocarcinoma, UCEC uterine corpus endometrial carcinoma, BRCA breast carcinoma, GBM glioblastoma multiforme, ACC adrenocortical carcinoma, UCS uterine carcinosarcoma, PRAD prostate adenocarcinoma, LIHC liver hepatocellular carcinoma, LGG lower grade glioma, KIRP kidney renal papillary cell carcinoma, KICH kidney chromophobe, KIRC kidney renal clear cell carcinoma

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