Parainflammation decreases in response to NSAID treatment in mouse organoids. a The adenoma/MIN log2 expression fold ratio of PI genes (x-axis) against the sulindac-treated adenomas/adenoma log2 expression fold ratio of PI genes (y-axis). Colors represent significance in the differential expression analyses (false discovery rate (FDR) <1 %). Along the x-axis it can be observed that 17 of 19 significant genes in adenoma/MIN are upregulated in the adenomas. Of those, 11 are significantly downregulated in the sulindac-treated samples and none are significantly upregulated. b
IFITM2/3 immunofluorescence in APCmin/+, adenoma and Sulindac-treated adenoma organoids. Both rows show different fields of same experiment.