TY - JOUR AU - Zhao, Xuefang AU - Emery, Sarah B. AU - Myers, Bridget AU - Kidd, Jeffrey M. AU - Mills, Ryan E. PY - 2016 DA - 2016/06/10 TI - Resolving complex structural genomic rearrangements using a randomized approach JO - Genome Biology SP - 126 VL - 17 IS - 1 AB - Complex chromosomal rearrangements are structural genomic alterations involving multiple instances of deletions, duplications, inversions, or translocations that co-occur either on the same chromosome or represent different overlapping events on homologous chromosomes. We present SVelter, an algorithm that identifies regions of the genome suspected to harbor a complex event and then resolves the structure by iteratively rearranging the local genome structure, in a randomized fashion, with each structure scored against characteristics of the observed sequencing data. SVelter is able to accurately reconstruct complex chromosomal rearrangements when compared to well-characterized genomes that have been deeply sequenced with both short and long reads. SN - 1474-760X UR - https://doi.org/10.1186/s13059-016-0993-1 DO - 10.1186/s13059-016-0993-1 ID - Zhao2016 ER -