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Fig. 5 | Genome Biology

Fig. 5

From: CHiCAGO: robust detection of DNA looping interactions in Capture Hi-C data

Fig. 5

CHiCAGO multiple testing approach schematic. a Empirical probability of reproducible interaction (used to generate weight profiles) as a function of interaction distance, generated on two replicates of GM12878 cells, assessed for the 100,000 top-scoring interactions. bd The effects of applying p value weighting to the GM12878 data. The arrow on the x-axis indicates the number of significant interactions called in the weighted data. Upon applying weighting, we see a decrease in the interaction distance amongst cis-interactions (b). P value weighting increases the mean read count of called interactions (c) and decreases the prevalence of trans-chromosomal interactions (d)

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