Fig. 5
From: CHiCAGO: robust detection of DNA looping interactions in Capture Hi-C data
CHiCAGO multiple testing approach schematic. a Empirical probability of reproducible interaction (used to generate weight profiles) as a function of interaction distance, generated on two replicates of GM12878 cells, assessed for the 100,000 top-scoring interactions. b–d The effects of applying p value weighting to the GM12878 data. The arrow on the x-axis indicates the number of significant interactions called in the weighted data. Upon applying weighting, we see a decrease in the interaction distance amongst cis-interactions (b). P value weighting increases the mean read count of called interactions (c) and decreases the prevalence of trans-chromosomal interactions (d)