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Fig. 4 | Genome Biology

Fig. 4

From: Tracing the expression of circular RNAs in human pre-implantation embryos

Fig. 4

CircRNA and mRNA expression pattern during human pre-implantation development. a The pattern of circRNAs percentage in their hosting genes changes during pre-implantation development based on the ratio of back-spliced reads in total reads at each junction locus, the equation is: back-spliced reads/(back-spliced reads + forward-spliced reads). b Comparison of the expression levels of circRNA hosting genes and other coding genes in each stage during pre-implantation development. The expression levels of the hosting genes only include linear transcripts by excluding circular transcripts (RPKMdiscounted = RPKM×(1-circRNA ratio in Fig. 4a). The expression levels of circRNA hosting genes are higher than those of other coding genes before the 8-cell stage, whereas the opposite pattern is observed after the 8-cell stage (***P value <0.001, *P value <0.1, Student’s t-test). c The CLR values comparison of hosting genes from maternal genes and zygotic genes, respectively, during human pre-implantation development. d The circRNA percentage in their hosting genes which are maternal genes and have circular transcripts detected before 4-cell stage, as 950 genes from 1554 maternal hosting genes

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