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Fig. 4 | Genome Biology

Fig. 4

From: MUFFINN: cancer gene discovery via network analysis of somatic mutation data

Fig. 4

Comparison of MUFFINN predictive power with different cancer mutation data for samples from 18 types of cancer and pan-cancer samples. Distribution of AUC of MUFFINN using direct neighbors on HumanNet for cancer genes annotated by a CGC and b the 20/20 rule with pan-cancer samples and samples for 18 types of cancer. The AUC for the pan-cancer data is indicated by red triangles and those for the 18 types of cancer are represented as box plots. The number of retrieved cancer genes annotated by c CGC and d the 20/20 rule in the top 100, 500, and 1000 candidates by MUFFINN with pan-cancer samples and samples for 18 types of cancer. BLCA urothelial bladder cancer, BRCA breast cancer, COADREAD colon and rectal adenocarcinoma, GBM glioblastoma multiforme, HNSC head and neck squamous cell carcinoma, KICH chromophobe renal cell carcinoma, KIRC clear cell kidney carcinoma, KIRP papillary kidney carcinoma, LAML acute myeloid leukemia, LGG lower grade glioma, LUAD lung adenocarcinoma, LUSC lung squamous cell carcinoma, OV ovarian serous cystadenocarcinoma, PRAD prostate adenocarcinoma, SKCM cutaneous melanoma, STAD stomach adenocarcinoma, THCA papillary thyroid carcinoma, UCEC uterine corpus endometrial carcinoma

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