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Table 2 Hypergeometric probability calculations for common VZ-induced changes between our study [2] and previous work considered by Sharma [1]

From: Response to “Variable directionality of gene expression changes across generations does not constitute negative evidence of epigenetic inheritance” Sharma, A. Environmental Epigenetics, 2015, 1-5

Previous dataset

Number of differentially expressed genes in dataset

Common with VZ G1R-G2R (Iqbal)

Probability

Common with DEHP G1R-G2R (Iqbal)

Probability

  

P = 21041

 

P = 21041

 
  

p(VZ) = 284

 

p(DEPH) = 325

 

F1 embryo male testis

83

0

1

0

1

F1 embryo E13 male testis

309

5

0.40

3

0.86

F1 embryo E14 male testis

162

2

0.65

2

0.72

F1 embryo E16 male testis

135

3

0.27

1

0.88

F2 embryo male testis

83

0

1

0

1

F3 embryo male testis

83

0

1

0

1

F3 adult male sertoli cells

383

10

0.04

9

0.14

F3 adult female granulosa cells

419

7

0.34

7

0.47

F3 adult female heart

113

0

1

2

0.52

F3 adult female kidney

451

9

0.16

9

0.26

F3 adult female liver

221

0

1

1

0.97

F3 adult female uterus

230

5

0.20

5

0.28

F3 adult male heart

113

1

0.79

2

0.52

F3 adult male kidney

93

2

0.36

1

0.77

F3 adult male liver

55

1

0.53

1

0.58

F3 adult male prostate

825

12

0.44

9

0.89

F3 adult male seminal vesicle

180

2

0.70

0

1

F3 adult female ovary

2555

29

0.86

31

0.94

F3 adult male testis

338

3

0.84

2

0.97

F3 adult male amygdala

224

2

0.81

1

0.97

F3 adult male hippocampus

71

1

0.62

0

1

F3 adult female amygdala

103

0

1

0

1

F3 adult female hippocampus

910

12

0.57

18

0.17

F3 adult male brain

642

3

0.99

5

0.97

F3 adult male basolateral amygdala

40

0

1

0

1

F3 adult male brain cortex

57

2

0.18

1

0.59

F3 adult male hippocampus CA1

74

0

1

0

1

F3 adult male hippocampus CA3

212

2

0.03

1

0.96

F3 adult female basolateral amygdala

48

1

0.48

0

1

F3 adult female brain cortex

79

0

1

0

1

F3 adult female hippocampus CA1

35

1

0.38

1

0.38

F3 adult female hippocampus CA3

25

0

1

0

1

F3 adult male ventral prostate

685

5

0.96

8

0.83

F3 adult male prostate epithelial cells

215

2

0.79

0

1

F3 embryo E13 male primordial germ cells

404

3

0.91

1

0.99

F3 embryo E16 male prospermatogonia

114

0

1

0

1

Cumulative (36 studies)

10769

125

0.96

121

0.99