Fig. 5
From: Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies
Karyotype heterogeneity of human B-ALLs increases upon engraftment into recipient mice. a Overview of B-ALL patient material used in this study. b Genome-wide copy number plots using ~1Â Mb bins for bone marrow cells of three B-ALL patients. For B-ALL A and B, respectively, 8 and 3 euploid cells are present (non-cancer cells). c Genome-wide copy number plots using ~1Â Mb bins for bone marrow cells of two mice, 28Â weeks after engraftment with B-ALL B. d Aneuploidy and heterogeneity scores for the analysed B-ALL patient material and engraftments B-1 and B-2. The orange triangle indicates the baseline level of aneuploidy and heterogeneity of the near-euploid B-ALL A