Fig. 6

Schematic summary of the findings. Cells in state A can die or enter the cell cycle, transitioning into the B state. B cells can either cycle to give rise to more B cells or transdifferentiate into C state cells. C state cells can cycle giving rise to new C state cells. The thickness of the arrows corresponds to the likelihood of the event (rates are reported above the arrows). Each of the cell types is characterized by expression of specific sets of surface molecules (top), secreted factors (middle) and transcription factors (bottom) as summarized in the box below