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Fig. 4 | Genome Biology

Fig. 4

From: A transcriptome-based global map of signaling pathways in the ovarian cancer microenvironment associated with clinical outcome

Fig. 4

A common cytokine signaling network of ovarian cancer cells and TAMs. Ligands are represented as “free floating” symbols, receptors as membrane-associated symbols. Ligands derived from tumor cells are shown in red, ligands originating from TAMs in blue, ligands expressed by both cell types at similar levels (less than tenfold difference in TPM) in purple. Each ligand or receptor is represented by one or more identical symbols according to their expression levels (1, 2, and 3 symbols corresponding to green, blue, and red, respectively in Fig. 2). The model is based on the data in Figs. 2, 9c and Table 1 and assumes that protein levels follow gene expression. Gene names are explained in Additional file 3: Datasets S4 and S5. Red asterisks denote components associated with a poor clinical outcome (based on Figs. 79). Ligands shown in red letters are expressed only in a subset of patients (Table 1) and associated with a short relapse-free survival (RFS) (Fig. 9c)

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