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Fig. 1 | Genome Biology

Fig. 1

From: Integrative genomic deconvolution of rheumatoid arthritis GWAS loci into gene and cell type associations

Fig. 1

Overview of eQTLs from the blood of RA subjects and canonical pathway enrichment of genes with eQTLs. a Circos plot for eQTLs mapped in whole blood from RA subjects. Outermost track of gray dots shows a Manhattan plot of cis-eQTLs (FDR < 5 %) with egenes with lowest p values labeled. The inner links connect trans-eQTLs to the associated egene (only trans-eQTLs with nominal p values <10−14 are shown for clarity). Blue links represent associations within the same chromosome whereas gray links represent associations that span across chromosomes. b egenes associated with eQTLs in RA whole blood samples were tested for enrichment with the MSigDB term database separately for egenes associated in cis (left) or in trans (right)

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