Fig. 4

Examples of expanding DNA modification and transcriptomic domains. The contour plot represents the correlation coefficients between the nearest neighboring probes, where high correlation (r = 1) is represented in white, no correlation (r = 0) in light green, and anti-correlation (r = −1) in dark green. a The plot shows correlations between 11 DNA modification probes representing a ~4 Mb region on chr14: 34,414,883–38,642,244. Three distinct domains with high inter-probe correlation were detected in the young individuals (1–20 years), while the boundaries of these domains merged in the old individuals (76–96 years). The middle-aged individuals (40–63 years) showed an intermediate pattern. b The plot shows correlations between 11 transcripts representing a ~1 Mb region on chr2:190,753,842–191,603,958. Like the DNA modification data, the young individuals show distinct transcriptomic boundaries that diminished with age