Fig. 2
Loss of tissue-specific DNA modification and gene transcription patterns in the aging brain. The histograms represent the densities of the permuted mean ICC coefficients between two different brain regions (cerebral cortex and cerebellum) from samples of all ages: a DNA modification (permuted p < 10−6); b transcriptome (permuted p < 10−6). The red dashed lines show the mean cortex–cerebellum ICCs in the older individuals (>75 years)