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Fig. 2 | Genome Biology

Fig. 2

From: Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma

Fig. 2

Evaluation of expression signatures associated with metastatic RCC across single cells. ad Gene set activation analysis for the metastatic signature (a and b) and clear cell RCC prognostic signature (c and d). a, c Positions of each dot and ellipse in Fig. 1d were fixed, and then each dot was colored (main panel) and indicated as drop lines (top and right panels) according to the estimated status for the given signatures. Gene Set Variation Analysis (GSVA) scores were normalized to normal kidney tissue expression profiles. b, d Boxplots show overall reciprocal differences in the expression signatures across normal kidney cortex, bulk cells of each population, and single cells. Boxes show 25th to 75th percentile with 10th and 90th percentile whiskers. *P <0.05, **P <0.01, ***P <0.001, two-tailed Student’s t-test

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