Skip to main content
Fig. 1 | Genome Biology

Fig. 1

From: Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma

Fig. 1

Profiling transcriptome of paired pRCC and mRCC at single-cell resolution. a Brief description of clinical course in a patient with metastatic RCC. b Schematic of scRNA-seq experiments from establishment of the patient-derived xenograft model to discovery of targetable subpopulations. c Hierarchical clustering heatmap and dendrogram based on inter-correlation of centroid global expression profiles across kidney cortex normal, bulk cells of each population, and single cells using Euclidean distance metric and average linkage. d Principal component analysis (PCA) of single-cell-resolved gene expression profiles based on the first two principal components. Ellipses represent 95 % confidence around each group

Back to article page
\