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Table 3 Performance metrics under simulation scenario 1 (distinct associations between cell types)

From: An evaluation of methods correcting for cell-type heterogeneity in DNA methylation studies

Method Number of false positives Power KS GIF \(\hat {K}\) a
Unadjusted 248 0.208 0.168 1.60
Ref-based 14 0.146 0.026 0.92
Ref-free 375 0.248 0.097 1.33 13
SVA 32 0.124 0.021 1.05 10
ISVA 14 0.134 0.004 0.97 12
EWASher 3 0.036 0.044 0.92
CellCDec 7 0.094 0.008 0.98
Deconf 13 0.178 0.023 0.93
RUV 36 0.170 0.018 1.04 43
  1. KS Kolmogorov–Smirnov statistic, GIF genomic inflation factor
  2. aEstimated latent dimension