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Table 1 Fixed parameters in the simulation design

From: An evaluation of methods correcting for cell-type heterogeneity in DNA methylation studies

Parameter Description
S Number of CpGs chosen to be associated with phenotype in simulation
μ k Mean of the cell-type-specific DMS effects for cell type k, over all S DMSs
σ k Standard deviation of cell-type-specific DMS effects for cell type k, over all S DMSs
σ jk Variability of individual deviations at probe j in cell type k
\(\alpha ^{(0)} = \left (\alpha _{1}^{(0)}, \alpha _{2}^{(0)}\right)^{\top }\) Expected proportion of the mixture from cell types 1 and 2 when the phenotype z i is zero.
\(\alpha ^{(Z)} = \left (\alpha _{1}^{(Z)}, \alpha _{2}^{(Z)}\right)^{\top }\) Average cell-type mixture proportions for cell types 1 and 2 for subjects with phenotype level Z (continuous or binary)
ρ Precision of simulated cell mixture distributions. A greater value corresponds to more clearly defined differences in cell-type proportions with respect to the phenotype