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Fig. 3 | Genome Biology

Fig. 3

From: OncoNEM: inferring tumor evolution from single-cell sequencing data

Fig. 3

Parameter estimation. a Dependence of OncoNEM results on inference parameters. Log Bayes factor of highest scoring model inferred with given parameter combination relative to highest scoring model overall. The inferred parameters (\(\hat {\alpha }=0.22\), \(\hat {\beta }=0.08\)) are close to the ground truth (α=0.2, β=0.1). A large range of parameter combinations around the ground truth parameters yield solutions close to the ground truth tree in terms of pairwise cell shortest-path distance and V-measure. The distance was normalized to the largest distance observed between any inferred tree and the ground truth. b Parameter estimation accuracy. FPRs and FNRs estimated by OncoNEM for various simulation settings with five replicates each. The blue lines mark the ground truth parameters. The grey lines mark the grid values over which FPR and FNR were optimized

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