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Fig. 6 | Genome Biology

Fig. 6

From: Single-CpG resolution mapping of 5-hydroxymethylcytosine by chemical labeling and exonuclease digestion identifies evolutionarily unconserved CpGs as TET targets

Fig. 6

SCL-exo id CpGs show low conservation among vertebrates. a Average PhastCons score around SCL-exo id CpGs found within a Meis1 ChIP-seq peak either in a 5000 bp window (left panel) or in a close-up view of 200 bp (right panel). b Screenshot of UCSC genome browser showing the conservation between species of sequences including a SCL-exo id CpG (boxed in red). c SCL-exo id CpGs were sorted into three groups: High conservation (PhastCons score between 0.75 and 1), Intermediate conservation (PhastCons score between 0.075 and 0.75), and No conservation (PhastCons score between 0 and 0.075). Box plots illustrate the distribution of the PhastCons score for the three groups of id CpGs. d Best ranked motif for each of the three groups of id CpGs sorted according to their conservation, as determined by the SeqPos motif tool from Cistrome

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