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Fig. 5 | Genome Biology

Fig. 5

From: Single-CpG resolution mapping of 5-hydroxymethylcytosine by chemical labeling and exonuclease digestion identifies evolutionarily unconserved CpGs as TET targets

Fig. 5

Association of 5hmCs with DNA motifs. a Logos of de novo motifs and transcription factor binding motifs retrieved by the SeqPos motif tool from Cistrome (http://cistrome.dfci.harvard.edu) in 100 bp sequences centered on SCL-exo id CpGs included in hMeDIP peaks. As a control, motif search was run on 100 bp sequences centered on randomly selected CpGs. For each logo, the associated p value and z-score are indicated. b, c CpG hydroxymethylation prefers RCGY to YCGR motifs. Average profiles of RCGY (b) and YCGR (c) motif densities (R = A or G, and Y = C or T) around 27,031 SCL-exo id CpGs with at least 30× coverage

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Genome Biology

ISSN: 1474-760X

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