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Fig. 2 | Genome Biology

Fig. 2

From: Spatiotemporal variation of mammalian protein complex stoichiometries

Fig. 2

Landscape of stoichiometry variations of protein complexes. a About half of the investigated protein complexes undergo stoichiometric variation across cancer cell lines and during reprogramming. Proteins were defined as variable complex members if they were detected as differentially expressed (adjusted p value <0.05) in at least on cell line or state tested. Protein complexes were defined as variable if they had > =20 % of their members being variably expressed. Stoichiometric changes are mediated by change in abundance of a small fraction of complex members (~22 %). b Both variable complexes and members significantly overlap in the two datasets tested. c In comparison to stable members, variable members of protein complexes show significantly lower co-expression with other complex members at the protein level. d The fraction of variable members is higher in chromatin remodeling complexes and cellular transporters. A total of 116 protein complexes are ranked according the fraction of regulated members identified in the 11 cell lines and reprogramming dataset. e Selected protein complexes are shown in a network representation. Variable members are colored depending on whether they were identified as “variable complex member” in the reprogramming (blue), 11 cell line (orange), or both datasets (red). Stable members are shown in gray. Edges between nodes are based on STRING [59]

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