Fig. 5

Simulations show changes in locus organization across cell types. a Contact map for 500 conformations for the α globin locus in mES cells. Simulations are performed as in Fig. 1, but using mES cell ChIP-seq and DNase-seq data, as shown in Additional file 11: Figure S9. b Difference between the contact maps in panel (a) and Fig. 1 c. Blue regions indicate contacts that were present in erythroblasts, but not mES cells, and yellow indicates contacts present in mES cells but not erythroblasts. c Plots comparing simulations and Capture-C data for MESs (data from Ref. [14]). d–f Similar plots but for the β globin locus