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Table 1 Genes associated with susceptibility to DENV in humans and mosquitoes

From: Genomic approaches for understanding dengue: insights from the virus, vector, and host

Host Gene Type of variation Method Associated with Reference(s)
Human MICB Genetic GWAS Severe dengue [153]
Human PLCE1 Genetic GWAS Severe dengue [153]
Mosquito Early trypsin Genetic QTL analysis Midgut infection [86, 87]
Mosquito Dicer-2 Genetic Candidate gene sequencing GxG interactions [93]
Mosquito Cecropin Transcriptomic Microarray/RNAi Midgut, salivary gland infection [66, 70]
Mosquito Defensin Transcriptomic Microarray/RNAi Midgut infection [70]
Mosquito DVRF1 Transcriptomic Microarray/RNAi Midgut infection [68]
Mosquito DVRF2 Transcriptomic Microarray/RNAi Midgut infection [68]
Mosquito Vacuolar ATPase Transcriptomic Microarray/RNAi Midgut infection [84, 189]
Mosquito High mobility group box protein (HMGB) Transcriptomic Microarray/RNAi Midgut infection [84]
Mosquito ML33 Transcriptomic Microarray/RNAi Midgut infection [186]
Mosquito NPC1b Transcriptomic Microarray/RNAi Midgut infection [186]
  1. GWAS genome-wide association study, GxG genotype-by-genotype, QTL quantitative trait loci, RNAi RNA interference