Skip to main content

Table 1 Genes associated with susceptibility to DENV in humans and mosquitoes

From: Genomic approaches for understanding dengue: insights from the virus, vector, and host

Host

Gene

Type of variation

Method

Associated with

Reference(s)

Human

MICB

Genetic

GWAS

Severe dengue

[153]

Human

PLCE1

Genetic

GWAS

Severe dengue

[153]

Mosquito

Early trypsin

Genetic

QTL analysis

Midgut infection

[86, 87]

Mosquito

Dicer-2

Genetic

Candidate gene sequencing

GxG interactions

[93]

Mosquito

Cecropin

Transcriptomic

Microarray/RNAi

Midgut, salivary gland infection

[66, 70]

Mosquito

Defensin

Transcriptomic

Microarray/RNAi

Midgut infection

[70]

Mosquito

DVRF1

Transcriptomic

Microarray/RNAi

Midgut infection

[68]

Mosquito

DVRF2

Transcriptomic

Microarray/RNAi

Midgut infection

[68]

Mosquito

Vacuolar ATPase

Transcriptomic

Microarray/RNAi

Midgut infection

[84, 189]

Mosquito

High mobility group box protein (HMGB)

Transcriptomic

Microarray/RNAi

Midgut infection

[84]

Mosquito

ML33

Transcriptomic

Microarray/RNAi

Midgut infection

[186]

Mosquito

NPC1b

Transcriptomic

Microarray/RNAi

Midgut infection

[186]

  1. GWAS genome-wide association study, GxG genotype-by-genotype, QTL quantitative trait loci, RNAi RNA interference