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Fig. 7 | Genome Biology

Fig. 7

From: Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease

Fig. 7

Interaction among IL23, miR223 and CLDN8. a IL23 controls the expression of miR-223 in NCM460 and Caco-2 cells. NCM460 is a human colon mucosal epithelial cell line. b miR-223 is upregulated in the colonic mucosa of mice with TNBS-induced colitis. c The anti-IL23P19 therapy reduces the expression of miR-223. d Antagomir223 upregulates the RNA expression of CLDN8. e The proposed IL23/miR-223/CLDN8 pathway. Activation of the IL23 cascade upregulates the pro-inflammatory miR-223. By targeting CLDN8, miR-223 impairs intestinal barrier, leading to the development of IBD. M: Macrophage; DC: Dendritic cells. *P <0.05, **P <0.01, ***P <0.001 as compared with the control

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Genome Biology

ISSN: 1474-760X

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