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Fig. 2 | Genome Biology

Fig. 2

From: Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease

Fig. 2

Identification of CLDN8 as a novel target controlled by the IL23 pathway in IBD patients. a Quantitative PCR of CLDN8 in colonic inflamed mucosa of IBD patients. CD: Crohn’s disease (n = 50); UC: ulcerative colitis (n = 50); NT: normal subjects (n = 50). ***P <0.001 as compared with normal controls. b Representative immunostaining of CLDN8 in IBD-inflamed tissues and normal intestinal. Magnification of the images is 200-fold. IOD: Integrated optical densities of CLDN8 in colonic inflamed mucosa of IBD patients. **P <0.01 as compared with normal controls. c Anti-IL23P19 treatment reverses the downregulation of CLDN8 in TNBS-induced colitis tissues. *P <0.05, ***P <0.001 as compared with the controls. d Representative immunostaining of CLDN8

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Genome Biology

ISSN: 1474-760X

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