Fig. 4From: deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolutionTemporal dissection of mutational processes. Mutations called from a cohort of five LUAD (circles) and LUSC (triangles) patients with multi-region sequencing were temporally dissected into trunk and branch mutations, described previously in [9]. One patient (L002) had a tumor exhibiting an adenosquamous histological subtype, with separate regions being of different histology. For each patient, the fraction of contribution of signatures associated with smoking (a) and APOBEC activity (b) was determined in the trunk and branch mutations. The smoking signature was seen at higher fractions in the trunk mutations (blue) than the branch mutations (red), whereas the signature of APOBEC activity was seen to contribute more to the LUAD branch mutations than LUAD trunk mutations or LUSC trunk or branch mutationsBack to article page