Skip to main content
Fig. 1 | Genome Biology

Fig. 1

From: deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

Fig. 1

deconstructSigs workflow and output. a Given an input tumor profile and reference input signatures, deconstructSigs iteratively infers the weighted contributions of each reference signature until an empirically chosen error threshold is reached. b Example of the plot generated by the command ‘plotSignatures’. The top panel is the tumor mutational profile displaying the fraction of mutations found in each trinucleotide context, the middle panel is the reconstructed mutational profile created by multiplying the calculated weights by the signatures, and the bottom panel is the error between the tumor mutational profile and reconstructed mutational profile, with SSE annotated

Back to article page

Genome Biology

ISSN: 1474-760X

Contact us