Fig. 6

GTEx RNA-seq data show increased lncRNA expression variability in multiple human tissues. Inter-individual variability of multi-exonic MiTranscriptome lncRNA (green) and mRNA (blue) transcripts analyzed in GTEx RNA-seq dataset [64]. Twenty donors per tissue are analyzed (Additional file 2J). Standard deviation is normalized to the mean expression among all 20 analyzed donors for each tissue. Only transcripts expressed in the given tissue in at least one donor (RPKM >0.2) are displayed. Number of transcripts in each box from left to right: LCL (lncRNAs: 28,571; mRNAs: 102,449), adipose (lncRNAs: 38,060; mRNAs: 113,688), artery (lncRNAs: 29,965; mRNAs: 108,082), cerebellum (lncRNAs: 44,912; mRNAs: 115,039), heart (lncRNAs: 32,827; mRNAs: 111,564), lung (lncRNAs: 39,909; mRNAs: 117,901), muscle (lncRNAs: 31,507; mRNAs: 106,099), nerve (lncRNAs: 39,167; mRNAs: 115,038), and thyroid (lncRNAs: 40,099; mRNAs: 116,206). Median expression values from left to right: LCL: 0.55, 0.27, adipose: 0.66, 0.32, artery: 0.59, 0.30, cerebellum: 0.60, 0.33, heart: 0.66, 0.36, lung: 0.63, 0.31, muscle: 0.85, 0.41, nerve: 0.54, 0.26, and thyroid: 0.56, 0.27. The box plots display the full population but P values are calculated using Mann–Whitney U test on equalized sample size (***P <10^–16). Data from chromosomes X, Y were discarded and outliers are not displayed