Fig. 4
From: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum
5hmC estimates generated using this approach were validated in an independent set of matched prefrontal cortex and cerebellum samples. Estimates of 5hmC at the 1,000 loci showing the highest levels of 5hmC in the discovery cohort were highly consistent and significantly correlated across datasets in both (a) the prefrontal cortex (R = 0.52, P = 8.96E-36) and (b) the cerebellum (R = 0.71, P = 7.42E-54). The red line denotes our threshold for robust 5hmC detection. (c) 5hmC differences between prefrontal cortex and cerebellum at the 1,000 top-ranked TS-HMPs identified in the discovery cohort were significantly correlated with differences identified at the same sites in the validation cohort (R = 0.49, P = 6.32E-33)