Fig. 2
From: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum
Hydroxymethylation is enriched in specific genomic features in brain. a Hydroxymethylated loci are significantly under-enriched in CpG islands, shores, and shelves and (b, c) significantly enriched in the gene body. d Across both brain regions sites with ‘detectable’ 5hmC are enriched in alternative last exons, cassette exons, and mutually exclusive exons, and under-enriched in alternative first exons and constitutive exons. The level of enrichment was determined by Fisher’s exact test. QC: quality control; CGI: CpG island; SHO: CpG island shore; SHE: CpG island shelf; nonCGI, NC: outside CpG islands; UA: unannotated; A3SS: 3’ splice site; A5SS: alternative 5’ splice site; AFE: alternative first exon; ALE: alternative last exon; CE: cassette exon; CNE: constitutive exon; EI: exon isoforms; II: intron isoforms; IR: intron retention; MXE: mutually exclusive exon