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Fig. 5 | Genome Biology

Fig. 5

From: Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients

Fig. 5

Characterization of the in-house developed AR inhibitor VPC-13566. a Dose-response curve illustrating the inhibiting effect of the VPC-13566 and enzalutamide on the AR transcriptional activity in PC3 cells transfected with wild-type AR plasmid. Data points represent the mean of three independent experiments performed in four replicates each. Error bars represent the standard error of the mean ± SEM for n = 12 values. b The specific binding to the BF3 site was confirmed by BAG1L peptide (1-20) displacement using a TR-FRET assay. c The effect of VPC-13566 on PC3 cell viability. % cell viability is plotted in dose dependent manner. Data points represent the mean ± SEM of two independent experiments performed in quadruplicate

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Genome Biology

ISSN: 1474-760X

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