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Fig. 6 | Genome Biology

Fig. 6

From: Isoform prefiltering improves performance of count-based methods for analysis of differential transcript usage

Fig. 6

TPR and FDR for DEXSeq-noaggreg, with various degrees of isoform-guided annotation filtering. The performance evaluation is stratified according to the degree of isoform dominance (the difference in relative abundance between the two most highly expressed isoforms of a gene, indicated in the panel headers as e.g. [0.000,0.333)). Excluding lowly expressed transcripts from the annotation catalog before defining the DEXSeq-noaggreg counting bins improves the control of FDR, with negligible loss (or even a slight gain) of power. The total number of genes (n) and the number of genes affected by DTU (n.ds) in each category are indicated in the panel headers

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