Fig. 5From: FBXO32, encoding a member of the SCF complex, is mutated in dilated cardiomyopathyHypothetical model of impaired autophagy flux mediated by the mutated FBXO32. a SCF complex containing FBXO32 induces the ubiquitination and subsequent degradation of target proteins. b Mutation in FBXO32 results in an inactive SCF complex, which stabilizes selective proteins regulating autophagy resulting in heart failureBack to article page