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Fig. 2 | Genome Biology

Fig. 2

From: Population whole-genome bisulfite sequencing across two tissues highlights the environment as the principal source of human methylome variation

Fig. 2

DNA methylation footprint in adipose tissue and blood. Datasets were merged within tissues, keeping only sites covered ≥12-fold, and the MethylseekR software [26] was employed to identify unmethylated and low-methylated footprints in adipose and blood. Shown are Venn diagrams describing tissue-specificity of identified (a) unmethylated regions (UMR) and (b) low-methylated regions (LMR). For overlapping areas, numbers indicate percentage of overlap based on adipose tissue and blood as indicated. c Histograms display the number of tissue-shared and adipose-specific UMRs overlapping with ranked H3K4me3 bins (see text; top 5 % are shown). d Adipose LMRs and adipose-specific UMRs overlapped with ranked H3K4me1 bins (top 5 % are shown)

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Genome Biology

ISSN: 1474-760X

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