Fig. 1

Comparison of sequencing-derived and array-derived methylation data. 450 K methylation array data were available for adipose tissue, and methylation values for CpG-sites jointly interrogated by both whole-genome bisulfite sequencing and the array were extracted for each individual. Shown are Pearson’s correlation coefficients derived from comparing array to sequencing methylation data for jointly interrogated CpG-sites for (a) samples at indicated mean genome coverage (black diamonds), with blue crosses indicating the number of jointly detected sites per sample, (b) CpG-sites at indicated coverage across all samples, (c) CpG-sites displaying 0 to 20 % (blue crosses), >20 to 40 % (red diamonds), >40 to 60 % (green points), or >60–100 % (purple triangles) methylation difference between forward and reverse strands at indicated sequencing coverage