Fig. 5
From: Meta-analysis of RNA-seq expression data across species, tissues and studies
Inter-tissue distance matrices are conserved across species. a Within-species inter-tissue distances (JSD½) are plotted between pairs of species. Heat maps along the diagonal show the magnitude of inter-tissue distances for a particular species. b The relative ordering and magnitude of distances between tissues within species are shown. Distances between nodes along the x-axis represent the distance between the tissues at nodes i and i + 1 respectively. Vertical lines connecting homologous tissues are for visualization purposes. c A schematic model of the relationship between interspecies and intraspecies tissue distances as a function of evolutionary divergence. The red and black graphs represent the distances between four tissues (T1 to T4) in two different species. The graphs were drawn such that the mean distance between tissues in a species exceeds the interspecies distance between homologous tissues by roughly the observed ratio for a human–macaque comparison (bottom), a human–mouse comparison (middle), or a human–chicken comparison (top), and to agree with the result above that relative tissue differences tend to be conserved across species