Fig. 1

Samples cluster largely by tissue across various studies and using a variety of distance metrics. Heat maps of the extent of interspecies tissue clustering, defined as the proportion of samples clustering most closely with a sample of a homologous tissue in a different species. Each heat map row represents a single set of samples assessed using various normalization methods and distance metrics (columns). a Representative samples (one per tissue/species) from four datasets spanning 11 species and from 6–13 tissues assessed over 4,547 common amniote orthologs. Lin1 and Lin2 represent identical library preparations sequenced at different times. b Mouse and human (*macaque was substituted for Merkin as no humans were assessed) samples assessed among the five tissues common to all studies (brain/cerebellum, testis, heart, kidney, and liver) over 11,850 human-mouse orthologs. c Mouse samples from each study paired with matched human tissues sequenced as part of the GTEx study assessed over 11,850 human/mouse orthologs in five common tissues