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Table 3 Shared chromatin related and epigenetic regulator genes altered by CR and LA feeding

From: Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging

Ensembl ID

Associated gene name

Description

AL versus CR log2 FC

AL versus CR FDR

AL versus AL+ LA log2 FC

AL versus AL+ LA FDR

ENSRNOG00000001442

Por

NADPH--cytochrome P450 reductase [Source:UniProtKB/Swiss-Prot;Acc:P00388]

1.24

8.58 × 10−06

0.75

1.19 × 10−02

ENSRNOG00000043098

Mt2A

Metallothionein-2 [Source:UniProtKB/Swiss-Prot;Acc:P04355]

1.06

7.02 × 10−04

1.30

4.81 × 10−05

ENSRNOG00000048961

Bhlhe41

Bhlhe41

1.06

5.45 × 10−04

0.92

7.17 × 10−03

ENSRNOG00000047374

Gnas

GNAS isoform GNASL [Source:RefSeq peptide;Acc:NP_062005]

0.99

2.69 × 10−08

0.90

1.73 × 10−05

ENSRNOG00000008001

Rab3b

Ras-related protein Rab-3B [Source:UniProtKB/Swiss-Prot;Acc:Q63941]

0.89

4.16 × 10−04

0.57

3.70 × 10−02

ENSRNOG00000018958

Mt3

Metallothionein-3 [Source:UniProtKB/Swiss-Prot;Acc:P37361]

0.77

3.94 × 10−03

0.58

3.88 × 10−02

ENSRNOG00000005183

Rtf1

RNA polymerase-associated protein RTF1 homolog [Source:RefSeq peptide;Acc:NP_001102428]

0.58

4.50 × 10−03

0.73

4.32 × 10−05

ENSRNOG00000006816

Urb5

Ubiquitin protein ligase E3 component n-recognin 5 [Source:MGI Symbol;Acc:MGI:1918040]

−0.43

3.64 × 10−02

−0.44

2.97 × 10−02

ENSRNOG00000013837

Trp53bp1

Transformation related protein 53 binding protein 1 [Source:MGI Symbol;Acc:MGI:1351320]

−0.50

1.48 × 10−02

−0.53

9.34 × 10−03

ENSRNOG00000005544

Kansl1

KAT8 regulatory NSL complex subunit 1 [Source:MGI Symbol;Acc:MGI:1923969]

−0.53

2.46 × 10−02

−0.61

1.26 × 10−02

ENSRNOG00000004289

Kdm6a

Lysine (K)-specific demethylase 6A [Source:MGI Symbol;Acc:MGI:1095419]

−0.59

1.24 × 10−02

−0.55

7.33 × 10−03

ENSRNOG00000003220

H3f3c

Histone H3.3 [Source:UniProtKB/Swiss-Prot;Acc:P84245]

−0.72

4.50 × 10−02

−0.75

1.50 × 10−02

ENSRNOG00000011523

H2afy

Core histone macro-H2A.1 [Source:UniProtKB/Swiss-Prot;Acc:Q02874]

−0.73

2.56 × 10−03

−0.82

5.60 × 10−04

ENSRNOG00000015781

Ndst3

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 [Source:RefSeq peptide;Acc:NP_001178645]

−0.82

4.27 × 10−03

−0.77

8.10 × 10−03

ENSRNOG00000046636

HIST1H4B

Histone H4 Osteogenic growth peptide

−0.92

6.85 × 10−04

-1.27

8.54 × 10−08

ENSRNOG00000017714

Usp3

Ubiquitin carboxyl-terminal hydrolase 3 [Source:RefSeq peptide;Acc:NP_001020595]

−0.99

1.11 × 10−02

−0.99

1.37 × 10−02

ENSRNOG00000006689

Chd7

Chromodomain helicase DNA binding protein 7 [Source:MGI Symbol;Acc:MGI:2444748]

-1.09

3.92 × 10−03

−0.93

1.60 × 10−02

ENSRNOG00000014397

Zic2

zinc finger protein ZIC 2 [Source:RefSeq peptide;Acc:NP_001101862]

-1.81

5.00 × 10−04

-2.06

7.44 × 10−05

  1. Benjamini-Hochberg FDR <0.05; n = 6 per group (pooled two by two)