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Table 1 Mean survival of rats on the various diets used in this study and the number of DE genes compared with AL feeding

From: Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging

Rat cohortsa

Mean survival (days) from [10]

SE (days)

Number of DE genes compared with AL

AL

854

22

NA

*AL > CR

1000

33

1028

AL + LA > CR

859

57

986

*CR

1025

25

941

CR > AL

914

44

1435

*CR > AL + LA

1009

34

1233

AL + LA

858

27

1003

  1. aDiet switches are indicated by “>” and occurred at 12 months of age. Asterisks (*) indicate long-lived cohorts, all statistically significant versus AL. Benjamini-Hochberg false discovery rate <0.05; n = 6 per group (pooled two by two) for the RNA-seq; 10,620 genes expressed in total. NA not applicable, SE standard error