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Fig. 3 | Genome Biology

Fig. 3

From: MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data

Fig. 3

Module scores for individual cells for the top nine enriched modules (a) and decomposed Z-scores (b) for single-cell gene set enrichment analysis in the MAIT data set, using the blood transcription modules (BTM) database. The distribution of module scores suggests heterogeneity among individual cells with respect to different biological processes. Enrichment of modules in stimulated and non-stimulated cells is due to a combination of differences in the discrete (proportion) and continuous (mean conditional expression) components of genes in modules. The combined Z-score reflects the enrichment due to differences in the continuous and discrete components

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