Table 2 Traits and diseases from the NHGRI GWAS catalog with associated loci enriched for local meQTLs
Phenotype | N annot | Overlap | Fisher PV | OR | Perm Z | Perm PV | Perm QV |
|---|---|---|---|---|---|---|---|
Bone mineral density | 25 | 15 | 1.58E-07 | 9.03 | 6.530 | 4.40E-10 | 1.07E-07 |
Breast cancer | 34 | 17 | 8.28E-07 | 6.02 | 5.878 | 2.51E-08 | 3.05E-06 |
Blood pressure | 9 | 7 | 3.28E-05 | 21.06 | 5.551 | 1.63E-07 | 1.31E-05 |
Height | 90 | 31 | 1.25E-06 | 3.16 | 5.499 | 2.16E-07 | 1.31E-05 |
Major depressive disorder | 14 | 9 | 2.44E-05 | 10.84 | 5.452 | 2.80E-07 | 1.36E-05 |
Non-alcoholic fatty liver disease | 7 | 6 | 5.13E-05 | 36.10 | 5.413 | 3.47E-07 | 1.41E-05 |
Alzheimer’s disease | 17 | 10 | 2.54E-05 | 8.60 | 5.203 | 1.06E-06 | 3.67E-05 |
Rheumatoid arthritis | 37 | 16 | 1.84E-05 | 4.59 | 5.167 | 1.27E-06 | 3.86E-05 |
Hypertension | 10 | 7 | 9.59E-05 | 14.05 | 5.010 | 2.82E-06 | 7.62E-05 |
QRS duration | 8 | 6 | 1.80E-04 | 18.06 | 4.911 | 4.62E-06 | 1.08E-04 |
Crohn’s disease | 42 | 17 | 2.89E-05 | 4.09 | 4.900 | 4.89E-06 | 1.08E-04 |
Pulmonary function decline | 6 | 5 | 3.10E-04 | 30.10 | 4.803 | 7.79E-06 | 1.58E-04 |
IgG glycosylation | 70 | 23 | 8.67E-05 | 2.95 | 4.409 | 4.80E-05 | 8.98E-04 |
Systemic lupus erythematosus | 15 | 8 | 4.25E-04 | 6.88 | 4.199 | 1.18E-04 | 1.93E-03 |
Bone mineral density — spine | 5 | 4 | 1.82E-03 | 24.08 | 4.198 | 1.19E-04 | 1.93E-03 |
Hip geometry | 5 | 4 | 1.82E-03 | 24.08 | 4.173 | 1.32E-04 | 2.01E-03 |
Autism spectrum, attention deficit-hyperactivity, bipolar and major depressive disorders and schizophrenia combined | 19 | 9 | 5.72E-04 | 5.42 | 4.103 | 1.77E-04 | 2.52E-03 |
Mean corpuscular hemoglobin | 5 | 4 | 1.82E-03 | 24.08 | 4.084 | 1.90E-04 | 2.57E-03 |
Tuberculosis | 8 | 5 | 2.25E-03 | 10.03 | 4.031 | 2.36E-04 | 3.02E-03 |
Bipolar disorder and schizophrenia | 24 | 10 | 9.86E-04 | 4.30 | 3.799 | 5.85E-04 | 7.11E-03 |
Obesity-related traits | 165 | 40 | 7.21E-04 | 1.93 | 3.709 | 8.22E-04 | 9.52E-03 |