Table 1 Summary statistics for number of findings by analysis category

Part I: overall findings

Number of tests (billions)

16.7

1140.2

19,440.1

20,597.0

Fraction of tests significant at FDR = 1 %

4 × 10⁻³

3.7 × 10⁻⁷

7 × 10⁻¹⁰

–

P value threshold for FDR = 1 %

4.05 × 10⁻⁵

3.74 × 10⁻⁹

7.03 × 10⁻¹²

–

Number of tests significant at FDR = 1 %

67,752,610

426,958

13,672

–

Number of unique SNPs with meQTLs

4,426,992 (97.68 %)

36,916 (0.81 %)

11,204 (0.25 %)

4,532,060

Unique methylation sites with meQTLs

683,152 (15.03 %)

3819 (0.08 %)

286 (0.01 %)

4,544,738

Part II: by methylation site features

At MAF ≥ 0.05

Sites (with meQTLs)

683,152

3,819

286

4,544,738

With CpG-SNPs

75 %

45 %

35 %

33 %

With other SNPs

12 %

18 %

20 %

30 %

Without SNPs

13 %

37 %

45 %

37 %