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Fig. 2 | Genome Biology

Fig. 2

From: A novel ATAC-seq approach reveals lineage-specific reinforcement of the open chromatin landscape via cooperation between BAF and p63

Fig. 2

BAF is enriched at and promotes open chromatin sites with p63 binding. a ATAC-seq summit-centered heatmap of ATAC-seq signal in control (CTRLi) and BAF-loss (BAFi) conditions, as well as BAF ChIP-seq signal in the same regions for all ATAC-seq peaks. The ATAC-seq peaks are sorted in BAF-independent, lost, and gained groups. b Average diagram of BAF ChIP-seq signal at BAF-independent, lost, and gained open chromatin regions. c Scatter plot demonstrating the relative enrichment of BAF binding at gained/lost ATAC-seq peaks. The p63-motif containing ATAC-seq peaks are highlighted in blue. d Bar graph showing the − Log10 p-value of TF motifs identified from a de novo Homer motif search, based on the ATAC-seq peaks gained or lost with BAFi. e Comparison of top motifs identified from the ATAC-seq analysis with a known p63 motif (weighted matrix). f Bar graph showing the percentage of ATAC-seq peaks with the p63 motif in both total ATAC-seq peaks as well as in BAFi peak loss. g Average diagram of genome-wide open chromatin accessibility at p63 and CTCF regions comparing CTRLi and BAFi conditions. h Venn diagram showing the overlap of gene sets controlled by p63 and BAF in keratinocyte differentiation. i Gene Ontology analysis of the 236 genes shared by BAF and p63. bp base pair, kb kilobase pair, TF transcription factor

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