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Fig. 2 | Genome Biology

Fig. 2

From: Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2

Fig. 2

Motif enrichment in peak regions versus randomly selected background sequences. a, b For each transcription factor, the percentage of SHP peak regions in vehicle (Veh)- (a) or FGF19-treated samples (b) with motifs within +/-100 bp of the peak summits (peak) or the percentage in randomly selected sequences (bg) is shown. Randomly selected sequences are GC normalized to the peak region sequences. ‘Non-nuclear receptor (non-NR)’ binding motifs are for factors that are not in the nuclear receptor superfamily and ‘nuclear receptor (NR)’ motifs are all known nuclear receptor motifs listed in the JASPAR database. Motifs are ordered on the X-axis from smallest P value to largest P value from left to right based on the binomial test. ***P <1e-10, **P <0.01, *P <0.1. Note that with exception of PPARγ/RXRα in vehicle-treated sample, none of the nuclear receptor motifs has a P value smaller than 0.01

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